The Hidden Weight of Depression: Understanding Fatigue

Depression is a mental health condition that affects many people. One of the most common symptoms is feeling very tired or fatigued. In fact, more than 90% of people with major depressive disorder (MDD) experience fatigue. This tiredness can affect the body, mind, and emotions. Even when other symptoms of depression get better, fatigue often stays. This can make it hard for people to feel fully recovered and can affect their daily lives.

There are several reasons why people with depression feel so tired. First, there are changes in brain chemicals like serotonin, norepinephrine, and dopamine. These chemicals help control mood and energy levels. Second, the body’s immune system might get activated, causing inflammation that can increase fatigue. Third, stress hormones like cortisol can become unbalanced, adding to feelings of tiredness. Fourth, problems with metabolism, such as low levels of good cholesterol, have been linked to severe fatigue. Lastly, sleep problems, like trouble falling asleep or sleeping too much, can make fatigue worse. Understanding these causes can help doctors find better ways to treat fatigue in people with depression.